COVID-19 vaccine side-effects in dermal filler patients

The American Society for Dermatologic Surgery (ASDS) has issued a new guidance regarding side effects from the SARS-CoV-2 mRNA vaccine on dermal fillers.

“Guidance Regarding SARS-CoV-2 mRNA Vaccine Side Effects in Dermal Filler Patients”, provides data from the US Food and Drug Administration (FDA) on reactions from the mRNA vaccine. It also shares information for both dermal practitioners and patients about the occurrence of reactions based on the latest data available. The FDA data reports show that three participants out of 15,184 who received at least one dose of Moderna’s mRNA-1273 vaccine developed lip or facial swelling in areas of dermal filler placement, while no participants in the placebo group experienced any filler-related swellings or other adverse effects. Also, members of the Soft-tissue Fillers Guideline Task hope to publish a clinical guideline on the prevention and treatment of SARS-CoV-2 mRNA vaccine-related adverse events that could occur from soft tissue fillers.

As reported, the current ASDS guidance regarding dermal fillers and the vaccine are as follows:
• Dermal filler inflammatory events very seldom occur with both hyaluronic acid and non-hyaluronic acid fillers.
• Evidence suggests these reactions can be immunologically triggered by viral and bacterial illness, vaccinations (i.e., influenza vaccine) and dental procedures.
• These rare adverse events are temporary and respond to treatments such as oral corticosteroids and hyaluronidase, and often times resolve without treatment.
• Patients already treated with dermal fillers should not be discouraged or precluded from receiving vaccines of any kind. Patients who have had vaccines should not be precluded from receiving dermal fillers in the future.
• In the Moderna mRNA-1273 trial, three reactions were possibly related to dermal fillers out of 15,184 vaccine recipients. It is unknown how many subjects in the trial had previous treatment with dermal fillers.
• ASDS members should obtain a pertinent medical history on all patients.
• Dermal fillers should be administered by board-certified physicians who are experts in both the injection of dermal fillers and management of complications arising from them.

The guidance is meant to provide information, and provide direction as the vaccine is given to more people around the globe.

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