Galderma is stepping up to a growing challenge in aesthetic medicine: facial volume loss linked to medication-driven weight loss. As more patients experience these changes, both they and practitioners are looking for effective solutions.
Recently, Galderma shared final results from a unique nine-month phase IV study. The study shows that combining Sculptra® with Restylane® Lyft™ or Contour™ leads to lasting improvements in facial appearance, skin quality, and patient satisfaction. This data gives injectors solid, real-world insights to help guide successful, long-term treatment plans.
Meeting the aesthetic needs of post-weight-loss patients
Patients who lose weight due to medication often notice changes in their face, such as dry or sagging skin, hollow cheeks, and less facial definition. To help address these concerns, Galderma conducted a clinical trial in the U.S. using the SHAPE Up Holistic Individualised Treatment protocol. This approach combined the skin-rejuvenating effects of Sculptra with the lifting and hydrating benefits of Restylane products to improve cheek and jawline contours.
Patients received Sculptra with Restylane Lyft or Contour, followed by optional touch-ups at Week 4 and Week 8. The study allowed practitioners to tailor each treatment and achieve the best possible results using Galderma’s product range.
Efficacy, satisfaction, and skin quality improvements
Results from the nine-month data are notably strong:
- Skin hydration and radiance were significantly improved, thanks to Restylane’s hydrating properties and Sculptra’s collagen-stimulating effects.
- Subject satisfaction remained high throughout the trial:
- 88.6% “loved” the way treatment maintained their facial structure after facial volume loss.
- 85.7% said their face looked less gaunt or sunken.
- 91.4% would recommend the injectable combination post-weight loss.
- No treatment-related adverse events were reported, reinforcing the regimen’s safety profile.
What this means for aesthetic medicine practitioners
This study confirms that injectables work well for patients after weight loss and highlights the importance of personalised, long-term treatment plans in aesthetic care. With the SHAPE Up HIT™ approach, doctors can now restore facial structure and improve skin quality.
Galderma’s product range also helps boost patient confidence with more effective and personalised treatments.












